When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated
in red letters.
Dashes indicate identical nucleotides. Dots indicate gaps by comparison to the longest
sequence. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).
The nucleotide between parentheses at the beginning of exons comes from a DONOR-SPLICE (n from ngt). The first nucleotide from an INT-DONOR-SPLICE is underlined (n from ngt).
Exon names are shown between parentheses on the first line.
The Cysteines involved in the IG CH1, CH2 and CH3 intrachain disulfide bridge are shown with a larger letter C in purple.
The Cysteines involved in the H-L or H-H interchain disulfide bridge are shown with a larger letter C in black.
STOP-CODON is indicated by an asterisk.
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).
1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
A S T K G P S V F P L A P S S
X65284 ,IGHG1*01,(cDNA) (CH1) (G)CC TCC ACC AAG GGC CCA TCG GTC TTC CCC CTG GCG CCC TCC TCC
AF300437,IGHG1*02
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
K S T S G G T Q A L G C L V K D Y
X65284 ,IGHG1*01,(cDNA) (CH1) AAG AGC ACC TCT ... ... ... GGG GGC ACA CAG GCC CTG GGC TGC CTG GTC AAG GAC TAC
AF300437,IGHG1*02
_________BC_____________________ ___________CD_______
45.1 45.3 45.5
29 30 31 32 33 34 35 36 39 40 41 42 43 44 45 45.2 45.4
F P E P V T V S W N S G A L T S
X65284 ,IGHG1*01,(cDNA) (CH1) TTC CCC ... ... GAA CCG GTG ACC GTG TCG TGG AAC TCA GGC GCC CTG ACC AGC ... ...
AF300437,IGHG1*02
________ _________________________DE_____________
45.7 84.1 84.3 84.5 84.7 85.6
45.6 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
G V H T F P A V L Q S S
X65284 ,IGHG1*01,(cDNA) (CH1) ... ... GGC GTG CAC ACC TTC CCG GCT GTC CTA CAA TCC TCA ... ... ... ... ... ...
AF300437,IGHG1*02 --- --- --- --G --- --- ... ... ... ... ... ...
________________ _EF_____
85.4 85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98
G L Y S L S S V V T V P S S S L G
X65284 ,IGHG1*01,(cDNA) (CH1) GGA CTC TAC TCC CTC AGC AGC GTG GTG ACC GTG CCC TCC AGC AGC TTG ... ... ... GGC
AF300437,IGHG1*02 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ---
_______________________FG___________________________
99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
T Q T Y I C N V D H K P S N T K V D
X65284 ,IGHG1*01,(cDNA) (CH1) ACC CAG ACC TAC ATC TGC AAT GTA GAT CAC AAG CCC ... ... AGC AAC ACC AAG GTG GAC
AF300437,IGHG1*02 --- --- --- --- --- --- --C --- --- --- --- --- ... ... --- --- --- --- --- ---
119 120 121
K K V
X65284 ,IGHG1*01,(cDNA) (CH1) AAG AAA GTT G
AF300437,IGHG1*02 --- --- --- -
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
E P K S C D T T H T C P P C A
X65285 ,IGHG1*01,(cDNA) (H) AG CCC AAA TCT TGT GAC ACA ACT CAT ACA TGC CCA CCA TGC GCA G
AF300437,IGHG1*02 -- --- --- --- --- --- --- --- --C --- --- --- --- --- --- -
1.6 1.5 1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
A P E L L G G P S V F L F P P K P
X61311 ,IGHG1*01,(cDNA) (CH2) CA CCT GAA CTC CTG GGG GGA CCG TCA GTC TTC CTC TTC CCC CCA AAA CCC
AF300437,IGHG1*02 -- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
K D T L M I S R T P E V T C V V V D V
X61311 ,IGHG1*01,(cDNA) (CH2) AAG GAC ACC CTC ATG ATC ... TCC CGG ACC CCT GAG GTC ACG TGC GTG GTG GTG GAT GTG
AF300437,IGHG1*02 --- --- --- --- --- --- ... --- --- --- --- --- --- --A --- -
_________BC_____________________ ___________CD_______
45.1 45.3 45.5
29 30 31 32 33 34 35 36 39 40 41 42 43 44 45 45.2 45.4
S H E D P E V K F N W Y V D G V E V H
X61311 ,IGHG1*01,(cDNA) (CH2) AGC CAC GAA GAC CCT GAG GTC AAG TTC AAC TGG TAC GTG GAC GGC GTG GAG GTG CAT ...
________ _________________________DE_____________
45.7 84.1 84.3 84.5 84.7 85.6
45.6 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
N A K T K P R E E Q Y N
X61311 ,IGHG1*01,(cDNA) (CH2) ... ... AAT GCC AAG ACA AAG CCG CGG GAG GAG CAG TAC AAC ... ... ... ... ... ...
________________ _EF_____
85.4 85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98
S T Y R V V S V L T V L H Q D W L N
X61311 ,IGHG1*01,(cDNA) (CH2) AGC ACG TAC CGT GTG GTC AGC GTC CTC ACT GTC CTG CAC CAG GAC TGG ... ... CTG AAT
_______________________FG___________________________
99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
G K E Y K C K V S N K A L P A P I E
X61311 ,IGHG1*01,(cDNA) (CH2) GGC AAG GAG TAC AAG TGC AAG GTC TCC AAC AAA GCC ... ... CTC CCA GCC CCC ATC GAG
119 120 121 122 123 124 125
K T I S K A K
X61311 ,IGHG1*01,(cDNA) (CH2) AAA ACC ATC TCC AAA GCC AAA G
1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
G Q P R E P Q V Y T L P P S R
X61310 ,IGHG1*01,(cDNA) (CH3) GG CAG CCC CGA GAA CCA CAG GTG TAC ACC CTG CCC CCA TCC CGG
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
D E L T K N Q V S L T C L V K G F
X61310 ,IGHG1*01,(cDNA) (CH3) GAT GAG CTG ACC ... ... ... AAG AAC CAG GTC AGC CTG ACC TGC CTG GTC AAA GGC TTC
_________BC_____________________ ___________CD_______
45.1 45.3 45.5
29 30 31 32 33 34 35 36 39 40 41 42 43 44 45 45.2 45.4
Y P S D I A V E W E S S G Q P E N
X61310 ,IGHG1*01,(cDNA) (CH3) TAT CCC ... ... AGC GAC ATC GCC GTG GAG TGG GAG AGC AGT GGG CAG CCG GAG AAC ...
________ _________________________DE_____________
45.7 84.1 84.3 84.5 84.7 85.6
45.6 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
N Y K T T P P V L D S D
X61310 ,IGHG1*01,(cDNA) (CH3) ... ... AAC TAC AAG ACA ACG CCT CCC GTG CTG GAC TCC GAC ... ... ... ... ... ...
________________ _EF_____
85.4 85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98
G S F F L Y S K L T V D K S R W Q Q
X61310 ,IGHG1*01,(cDNA) (CH3) GGC TCC TTC TTC CTC TAC AGC AAG CTC ACC GTG GAC AAG AGC AGG TGG ... ... CAG CAG
_______________________FG___________________________
99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
G N V F S C S V M H E A L H N H Y T Q
X61310 ,IGHG1*01,(cDNA) (CH3) GGG AAC GTC TTC TCA TGC TCC GTG ATG CAT GAG GCT ... CTG CAC AAC CAC TAC ACG CAG
119 120
K S
X61310 ,IGHG1*01,(cDNA) (CH3) AAG AGC C
Created: 12/11/2002
Author: Nathalie Bosc
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